| | Pre-treatment | At 3 weeks | At 7 weeks | p value |
|---|
| Body weight, kg | 46.1 (7.7) | 47.5 (7.2)** | 48.2 (8.0)*** | 0.0003 |
| BMI, kg/m2 | 17.4 (2.1) | 18.1 (1.5)* | 18.3 (1.8)*** | 0.0008 |
| Total lean mass, kg | 36.1 (4.7) | 37.0 (4.5)** | 35.9 (4.6)†† | 0.0011 |
| Food intake, kcal/day | 1853 (264) | 1962 (318) | ND | 0.0360 |
| MEP, cmH20 | 99.7 (26.2) | 106.9 (34.7) | 102.0 (38.4) | 0.5413 |
| MIP, cmH20 | − 56.3 (12.6) | − 63.7 (14.2) | − 59.3 (12.0) | 0.2058 |
| Urinary NE on 24-h collection, μg/day | 268.7 (121.9) | 126.1 (48.3) | ND | 0.0063 |
| Pulmonary function test |
| FEV1, L | 0.85 (0.24) | 0.87 (0.20) | 0.86 (0.21) | 0.8963 |
| FEV1/FVC, % | 34.2 (6.9) | 33.0 (5.9) | 33.0 (6.4) | 0.5492 |
| %FEV1, % | 33.4 (9.0) | 34.4 (7.6) | 34.2 (8.1) | 0.7830 |
| VC, L | 2.53 (0.56) | 2.60 (0.51) | 2.58 (0.45) | 0.8298 |
| %VC, % | 80.6 (14.5) | 83.9 (12.1) | 83.6 (10.8) | 0.6316 |
| SGRQ |
| Symptoms | 66.4 (21.4) | 50.9 (22.3)* | 56.2 (17.4) | 0.0153 |
| Activity | 67.9 (11.4) | 70.6 (12.5) | 67.8 (17.3) | 0.6497 |
| Impacts | 40.3 (21.1) | 36.8 (16.6) | 44.4 (25.9) | 0.1197 |
| Total | 53.2 (16.6) | 49.8 (14.2) | 53.5 (21.0) | 0.3713 |
- Data are presented as means (SD)
- The resultant p values are represented. The variables were tested by a linear mixed effect model
- FEV1 forced expiratory volume in one second, FVC forced vital capacity, MEP maximal expiratory pressure, MIP maximal inspiratory pressure, NE norepinephrine level, SGRQ St. George Respiratory Questionnaire, VC vital capacity
- *p < 0.05, **p < 0.01, ***p < 0.001 by the least squares means Tukey’s honestly significant difference test, compared with pre-treatment values
- †p < 0.05, ††p < 0.01 by the least squares means Tukey’s honestly significant difference test, compared with the values at 3 weeks
