| |
Pre-treatment
|
At 3 weeks
|
At 7 weeks
|
p value
|
|---|
|
Body weight, kg
|
46.1 (7.7)
|
47.5 (7.2)**
|
48.2 (8.0)***
|
0.0003
|
|
BMI, kg/m2
|
17.4 (2.1)
|
18.1 (1.5)*
|
18.3 (1.8)***
|
0.0008
|
|
Total lean mass, kg
|
36.1 (4.7)
|
37.0 (4.5)**
|
35.9 (4.6)††
|
0.0011
|
|
Food intake, kcal/day
|
1853 (264)
|
1962 (318)
|
ND
|
0.0360
|
|
MEP, cmH20
|
99.7 (26.2)
|
106.9 (34.7)
|
102.0 (38.4)
|
0.5413
|
|
MIP, cmH20
|
− 56.3 (12.6)
|
− 63.7 (14.2)
|
− 59.3 (12.0)
|
0.2058
|
|
Urinary NE on 24-h collection, μg/day
|
268.7 (121.9)
|
126.1 (48.3)
|
ND
|
0.0063
|
|
Pulmonary function test
|
|
FEV1, L
|
0.85 (0.24)
|
0.87 (0.20)
|
0.86 (0.21)
|
0.8963
|
|
FEV1/FVC, %
|
34.2 (6.9)
|
33.0 (5.9)
|
33.0 (6.4)
|
0.5492
|
|
%FEV1, %
|
33.4 (9.0)
|
34.4 (7.6)
|
34.2 (8.1)
|
0.7830
|
|
VC, L
|
2.53 (0.56)
|
2.60 (0.51)
|
2.58 (0.45)
|
0.8298
|
|
%VC, %
|
80.6 (14.5)
|
83.9 (12.1)
|
83.6 (10.8)
|
0.6316
|
|
SGRQ
|
|
Symptoms
|
66.4 (21.4)
|
50.9 (22.3)*
|
56.2 (17.4)
|
0.0153
|
|
Activity
|
67.9 (11.4)
|
70.6 (12.5)
|
67.8 (17.3)
|
0.6497
|
|
Impacts
|
40.3 (21.1)
|
36.8 (16.6)
|
44.4 (25.9)
|
0.1197
|
|
Total
|
53.2 (16.6)
|
49.8 (14.2)
|
53.5 (21.0)
|
0.3713
|
- Data are presented as means (SD)
- The resultant p values are represented. The variables were tested by a linear mixed effect model
- FEV1 forced expiratory volume in one second, FVC forced vital capacity, MEP maximal expiratory pressure, MIP maximal inspiratory pressure, NE norepinephrine level, SGRQ St. George Respiratory Questionnaire, VC vital capacity
- *p < 0.05, **p < 0.01, ***p < 0.001 by the least squares means Tukey’s honestly significant difference test, compared with pre-treatment values
- †p < 0.05, ††p < 0.01 by the least squares means Tukey’s honestly significant difference test, compared with the values at 3 weeks
