Fig. 5
From: Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function
The role of cardiac baroreflex function for dynamic cerebral autoregulation. Thigh cuff release elicited a transient drop in arterial blood pressure and resultant tachycardia via the arterial baroreflex (a) and increase in cerebral vascular conductance (CVCi) via cerebral autoregulation (b). Vagal blockade (glycopyrrolate, GLY) attenuated this tachycardic response, and the rate of regulation (RoR) as an index of dynamic cerebral autoregulation was also inhibited in the vagal blockade condition compared to both control (CON) and β1-adrenergic blockade (metoprolol, MET) conditions, indicating that the baroreflex-induced tachycardia response plays an important role in dynamic cerebral blood flow regulation [51]