Fig. 1

Effect of 5-HT2A antagonist on the intruder-elicited increase on body temperature and heart rate. A Averaged physiological recorded data from the resident mice after vehicle (2.8% DMSO, 0.4 ml) or SR-46349B (5 mg/kg i.p.) showing body temperature (a), heart rate (b) and locomotor activity (c). The administration was made 30 min before the introduction of the intruder mouse into the home cage of the resident mouse. The caged intruder was removed 30 min after introduction. Asterisks indicate a significant difference from baseline value before injection *P < 0.05. Hashtags indicate a significant difference from baseline value prior to the introduction of the intruder ^#P < 0.05. B Log-dose regression analysis of drug effect on the intruder-elicited response on body temperature (a), heart rate (b) and locomotor activity (c). Each black dot represents area under the curve (AUC) during 30 min after the introduction of the intruder for individual cases. Each transparent circle represents the mean value of the cases for each treatment (n = 7, mean ± SEM). Dashed line in (a) indicates significant linear regression between the log-dose of SR-46349B and the intruder-elicited changes in body temperature P < 0.05