Fig. 7

Role of spinal noradrenergic signaling in increased preference index and antihypersensitivity effect from oral gabapentin in SNL rats. Oral vehicle or gabapentin (GBP, 100 mg/kg) were administered 2 h prior to and intrathecal saline (IT-Sal) or idazoxan (IT-Ida, 30 μg/rat) were administered 30 min prior to the shuttle maze measurement with the object on the short route in SNL rats 2–3 weeks after surgery. a Total counts during the shuttle maze measurement. b Preference index values are presented as the percentage of counts that animals chose the short route over the total counts. c Withdrawal thresholds in the hind paw ipsilateral to nerve injury were measured prior to the drug administration (baseline) and just after the shuttle maze measurement in SNL rats. Data are presented as changes from the baseline