Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia

Table 3 Electrocardiogram parameters of wild-type mice and transgenic mice overexpressing the HCN2 channel

ECG parameters	Test conditions^a	WT mice	HCN2-Tg mice
RR (s)	CTR	0.121 ± 0.013	0.113 ± 0.06
RR (s)	Hypokalemia	0.174 ± 0.015*	0.139 ± 0.022*
PQ (s)	CTR	0.039 ± 0.008	0.038 ± 0.005
PQ (s)	Hypokalemia	0.048 ± 0.004*	0.047 ± 0.005*
QT (s)	CTR	0.042 ± 0.006	0.042 ± 0.006
QT (s)	Hypokalemia	0.072 ± 0.005*	0.067 ± 0.003*
QTc (s)^b	CTR	0.119 ± 0.017	0.125 ± 0.007
QTc (s)^b	Hypokalemia	0.189 ± 0.022	0.179 ± 0.018*

ECG, Electrocardiogram
*Significant difference between the values of CTR and hypokalemia at p < 0.05 (t test) (n = 3–6)
^aThe control ECGs (CTR) were recorded before the mice were started on the K⁺-free diet. The ECGs in the hypokalemic condition (Hypokalemia) were recorded after the mice had been fed a K⁺-free diet for 6 weeks
^bQTc was calculated according to Bazett’s formula

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