HCN2-Tg | 5.4 mM [K+]o | 3 mM [K+]o | 3 mM [K+]o + IVA |
---|
RMP (mV) | − 82.1 ± 2.4 | − 91.2 ± 3.3 | − 93.4 ± 2.9* |
APD90 (ms) | 31.5 ± 1.6 | 37.1 ± 3.1 | 30.1 ± 2.2* |
- The summaries of RMP and APD90 in the 5.4 mM [K+]o, 3 mM [K+]o, and 3 mM [K+]o solutions, respectively, all of which contain 10 μM IVA
- HCN2-Tg Transgenic mice overexpressing the hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channel in the heart
- *Significant difference at p < 0.05 (paired t test) in the presence and absence of IVA (n = 6)