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Table 2 Summary of the parameters of induced action potentials in the myocytes of transgenic mice overexpressing the HCN2 channel in the heart

From: Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia

HCN2-Tg

5.4 mM [K+]o

3 mM [K+]o

3 mM [K+]o + IVA

RMP (mV)

− 82.1 ± 2.4

− 91.2 ± 3.3

− 93.4 ± 2.9*

APD90 (ms)

31.5 ± 1.6

37.1 ± 3.1

30.1 ± 2.2*

  1. The summaries of RMP and APD90 in the 5.4 mM [K+]o, 3 mM [K+]o, and 3 mM [K+]o solutions, respectively, all of which contain 10 μM IVA
  2. HCN2-Tg Transgenic mice overexpressing the hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channel in the heart
  3. *Significant difference at p  < 0.05 (paired t test) in the presence and absence of IVA (n = 6)