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Table 1 The summary of the parameters of the induced action potential in wild-type myocytes

From: Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia

WT

5.4 mM [K+]o

3 mM [K+]o

3 mM [K+]o + IVA

RMP (mV)

− 81.5 ± 1.0

− 95.0 ± 2.2

− 94.5 ± 1.1

APD90 (ms)

30.4 ± 1.8

31.5 ± 1.2

30.9 ± 1.1

  1. The summaries of RMP and APD90 in the 5.4 mM [K+]o, 3 mM [K+]o, and 3 mM [K+]o solutions, all of which contain 10 μM IVA (n  = 6)
  2. APD90 Action potential duration at 90% repolarization, IVA ivabradine, [K+]o extracellular K+ concentration, RMP resting membrane potential
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The Journal of Physiological Sciences

ISSN: 1880-6562

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