Fig. 5
From: Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia
The electrocardiogram (ECG) recordings of WT and HCN2-Tg mice after they were fed a K+-free diet for 6 weeks. a ECG of WT mouse under control conditions. b ECG of a WT mouse after 6 weeks on a K+-free diet. c ECG of HCN2-Tg mouse under control conditions. d ECG of a HCN2-Tg mouse after 6 weeks on a K+-free diet. Ventricular ectopy (VE) is indicated by red arrows in all cases. In a–d, the panels to the left show the expanded traces. e Serum K+ concentrations measured after the ECG recordings. N.S. Not signficant. f Summary of the incidence of VE. In each experiment, ECGs were recorded for 5 min to confirm the incidence of VE. Asterisk indicates significant difference (χ2 test, p < 0.01) (color figure online)