Fig. 5From: Renal involvement in the pathogenesis of mineral and bone disorder in dystrophin-deficient mdx mouseSchematic model indicating the mineral and bone disorder in mdx mice. Dramatic muscle degeneration and immobilization play a role in hypercalcemia, and renal dysfunction is partly triggered by hypercalcemia and dehydration. Renal dysfunction and increased PTH levels contribute to lower bone density in adult mdx miceBack to article page