Fig. 5

Effects of silibinin on cortical oxidative damage (lipid peroxidation, nitrite, superoxide dismutase, and catalase levels. Silibinin exerted antioxidant effects on the cortex of APP/PS1 mice. Treatment with silibinin for 8 weeks reduced the MDA content and increased SOD, NO, and CAT activity in APP/PS1 mice. Data are presented as the means ± SEM from five animals per group. ^###p < 0.001 compared with the WT mice; ***P < 0.001 compared with the placebo group