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Fig. 4 | The Journal of Physiological Sciences

Fig. 4

From: Natural silibinin modulates amyloid precursor protein processing and amyloid-β protein clearance in APP/PS1 mice

Fig. 4

Silibinin reduces Aβ plaque deposits and soluble Aβ1-42, Aβ1-40 in APP/PS1 mice. Effects of silibinin on attenuating Aβ deposition in the hippocampus of APP/PS1 transgenic mice. The number of Aβ plaques and levels of soluble Aβ1-42 and Aβ1-40 were significantly reduced in the silibinin-treated groups. Images of the hippocampus from the a WT mice, b placebo group, c 100 mg/kg silibinin group, and d 200 mg/kg silibinin groups (images were captured using a high power 40× objective). e Quantification of Aβ deposits in each group. Results were calculated as the percentage of the Aβ area. f Soluble Aβ1-40 levels in the hippocampus of APP/PS1 mice. g Soluble Aβ1-42 levels in the hippocampus of APP/PS1 mice. Data are presented as the means ± SEM from five animals per group and four sections from each animal. ###p < 0.001 compared with the WT mice and **p < 0.01, ***p < 0.001 compared with the placebo group

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