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Fig. 3 | The Journal of Physiological Sciences

Fig. 3

From: Natural silibinin modulates amyloid precursor protein processing and amyloid-β protein clearance in APP/PS1 mice

Fig. 3

Silibinin improvement of spatial memory in Morris water maze test. Effects of silibinin on learning and memory deficits in the Morris water maze. Silibinin groups exhibited significant increases in time spent in the target quadrant and number of platform crossings. a Swimming speed in the training period. b Escape latency in the training period. c Mean time spent in the target quadrant in probe trial. d Mean number of platform crossings during the probe trial. e Representative traces of each group. The data are presented as means ± SEM and were analyzed with a one-way ANOVA, from ten mice per group, ##p < 0.01 and ###p < 0.001 compared with the WT mice; *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the placebo group

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