Fig. 1

Silibinin increases spontaneous alternation behavior in the Y-maze effects of silibinin on learning and memory deficits of APP/PS1 mice in the Y-maze test. The 8-week silibinin treatment significantly increased spontaneous alternation behaviors in APP/PS1 mice. a Alternations (%) in the Y-maze test. b The total number of arm entries in the Y-maze test. The data are presented as means ± SEM and were analyzed with a one-way ANOVA, N = 10 animals per group, ^###p < 0.001 compared with the WT mice; **p < 0.01 compared with the placebo group