Renin–angiotensin system research: from molecules to the whole body

Table 1 RAS-dependent hypertensive and hypotensive mice models

Mouse strains	Human RAS	Mouse RAS	SBP
Wild-type mice	–/–	RN/AG	Normal
hRN mice	RN/–	RN/AG	Normal
hAG mice	–/AG	RN/AG	Normal
hRN & hAG mice^a	RN/AG	RN/AG	Increased
PIH^c	Paternal RN/maternal AG	RN/AG	Increased
Non-PIH^d	Maternal RN/paternal AG	RN/AG	Normal
mAG-KO mice^b	–/–	RN/–	Decreased
mRN-KO mice	–/–	–/AG	Decreased

RN renin gene, AG angiotensinogen gene, – absence, h- human, m- mouse, KO knockout, SBP systolic blood pressure, increased or decreased, versus wild-type mice
^aTsukuba hypertensive mice
^bTsukuba hypotensive mice
^cPregnancy-induced hypertensive mice (i.e., hAG-females mated with hRN-males)
^dNon-hypertensive transgenic pregnant mice (i.e., hRN-females mated with hAG-males)

ISSN: 1880-6562