Mild hyperbaric oxygen: mechanisms and effects

Table 1 Effects of exposure to mild hyperbaric oxygen reported in previous studies

	Species	Effects	References
Metabolic syndrome	SHR/NDmcr-cp rat	Inhibition of metabolic syndrome	[3]
Type 2 diabetes	GK rat	Inhibition of type 2 diabetes	[4, 36, 37]
	OLETF rat	Inhibition of type 2 diabetes	[38]
	GK rat	Improvement of type 2 diabetes	[39]
Diabetes-induced cataracts	Repeated inbreeding of diabetic mouse	Inhibition of cataracts	[46]
Hypertension	SHR	Inhibition of hypertension	[5]
Arthritis	Collagen-induced DA rat	Inhibition of arthritis	[19]
Parkinson’s disease	MTPT-injected C57BL/6JJmsSlc mouse	Inhibition of decrease in dopaminergic neuron	[86]
Pigmentation	Male subject irradiated with UVB	Melanin pigmentation turns light	[62]
Pigmentation	Female subject	Senile spot size becomes small	[62]
Proliferation	Aged hairless (Hos, HR-1) mouse	Improvement of proliferative activity of epidermal basal cell	[60]
Metabolism	Human	Decrease in SpO2, increase in resting HR and energy expenditure	[20]
Skeletal muscle fiber	Wistar rat	Increase in oxidative capacity	[63, 64]
	Wistar rat	Inhibition of atrophy	[83]
	Aged ICR mouse	Improvement of oxidative capacity	[69]
Spinal motoneuron	Wistar rat	Increase in oxidative capacity	[63, 64]
Spinal motoneuron	GK rat	Improvement of oxidative capacity	[44]
Infertility	Woman with intractable infertility	Improvement of the outcome of in vitro fertilization	[96]

SHR spontaneously hypertensive rat, GK Goto-Kakizaki, OLETF Otsuka Long-Evans Tokushima Fatty, DA dark Agouti, UVB ultraviolet B, ICR Institute of Cancer Research, MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, SpO2 peripheral oxygen saturation, HR heart rate

ISSN: 1880-6562