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Fig. 6 | The Journal of Physiological Sciences

Fig. 6

From: Identification and classification of a new TRPM3 variant (γ subtype)

Fig. 6

Temperature-activated currents in Xenopus oocytes expressing mouse TRPM3α2. a, d Representative traces of TRPM3α2 currents activated by rapid (a) or slow (d) temperature changes up to 45 °C in Xenopus oocytes. Pregnenolone sulfate (PS, 100 μM) was applied after the temperature stimulus and the membrane potential was held at − 60 mV. b, e Temperature–current profiles from the traces in a and d, respectively. The x- and y-axes show temperature (°C) and current (μA), respectively. c, f Arrhenius plots from the traces in a and d, respectively. The lower and upper x-axes show 1000/temperature (K) and temperature (°C), respectively, whereas the y-axis shows the common logarithmic plot of current size. Q10 values were calculated from the approximate lines shown in black. The intersection of the two linear-fitted lines was defined as a temperature threshold as shown by the dashed line. g Comparison of the temperature thresholds for rapid and slow heat-evoked TRPM3α2 activation. Each column represents the mean ± SEM of 6–8 oocytes. Statistical significance was assessed using Student’s t test

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