Fig. 6From: Integrative and theoretical research on the architecture of a biological system and its disorderSchematic diagrams illustrating the implication of EAD developments in lethal arrhythmias. a Global AP duration (APD) heterogeneity in the ventricular wall (transmural dispersion of repolarizations) and formation of ectopic beats. b A possibility of the emergence of local APD heterogeneities (intralayer dispersion of repolarizations in the mid-myocardial layer) by exhibiting multi-stable APs, and an association to arrhythmogenic substrate formation. Endo endocardial layer, Mid Mid-myocardial layer, Epi Epicardial layerBack to article page