Fig. 7
The signaling pathway of P2Y2 receptor agonist stimulated HCO3− secretion. Representative immunoblotting and densitometric analysis of CFTR expression in control and omeprazole-treated Caco-2 cells (a). The rate of peak MRS2768-stimulated HCO3− secretion by control (b), and 400-ng/ml omeprazole-treated Caco-2 monolayers (c) that were induced by agonist or antagonist. The pH of apical culture media of Caco-2 monolayers at 24 h after culture media change (d). *P < 0.05, **P < 0.01, ***P < 0.001 compared with the corresponding vehicle group (n = 6)