Fig. 4

Effects of NS8593 on the basal [Mg²⁺]_i. a, b Each symbol represents mean ± SE of [Mg²⁺]_i obtained from 5 cells. Cells were perfused with Ca²⁺-free Tyrode’s solution except during the period of perfusion with NMDG Tyrode’s solution indicated by the line with arrows in b (0Na). Gray bars indicate the period of administration of 10 μM NS8593. *0.01 ≤ p < 0.05, **p < 0.01 versus the average of [Mg²⁺]_i just before the drug administration (at time − 2 min). c Columns summarize the change of [Mg²⁺]_i (Δ[Mg²⁺]_i) 50–60 min after application of naltriben (Fig. 3a, b) or NS8593 (a, b). Gray or white columns show mean ± SE of the data obtained, respectively, with or without extracellular Na⁺