Fig. 3
From: Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus
Possible roles of GABA in SCN cellular coupling. a GABA acts as both a synchronizer and destabilizer. b A phase delay shift results in bimodal neuronal activity in the intact SCN slice; however, after the application of GABAA receptor antagonists, circadian rhythms in the dorsal and ventral SCN are dissociated. c Long-day photoperiods change the intracellular chloride concentration in the dorsal SCN and decoupled circadian rhythms between the dorsal and ventral SCN. d Hypothetical model of the astrocytic-neuronal intercellular axis in the SCN