Fig. 6

CREB-dependent and independent upregulation of Kv7.1 by DHT and isoproterenol (ISO). Expression of Kv7.1 mRNA in cardiomyocytes was assessed after silencing CREB; CREB siRNA and scrambled siRNA (Nega siRNA) were used. Ventricular cardiomyocytes were cultured with 3 nM DHT (a) or 0.1 µM ISO (b) for 24 h with or without CREB siRNA. Data are expressed as mean ± SEM (n = 5 or 6). *p < 0.05 vs Nega siRNA (DHP, ISO)