Fig. 5
Expression of lysosomal degradation-related proteins of the SN in MPTP mice after treadmill exercise. Representative western blot showing LAMP2 and cathepsin L levels in the SN for all groups of mice are presented. a–c LAMP2 and cathepsin L were decreased in MPTP mice compared with C57BL mice, and the levels of those proteins in the SN of MPTP mice were increased after treadmill exercise. β-actin was probed as an internal control. d, e Correlation analysis of LAMP2 and cathepsin L with α-syn, respectively. Six mice per group were assayed in triplicate in western blot analysis. LSD post hoc test after ANOVA. Values are mean ± SEM. Filled circle indicates the saline control group (CON, n = 6), filled square indicates the MPTP treatment with probenecid group (MPTP, n = 6), and filled triangle indicates the MPTP treatment with probenecid plus treadmill exercise group (MPTP-TE, n = 6)