Fig. 2

Oxytocin (OXT)-monomeric red fluorescent protein 1 (mRFP1) in the supraoptic nucleus (SON) (A-a, B-a–d), the paraventricular nucleus (PVN) (A-b, B-e–h) and the medial nucleus of the solitary tract (mNTS) (A-c, B-i–l) 0, 12, 24, and 48 h and 1 week after administration of cisplatin. The average mRFP1 fluorescence intensities are shown for the SON (A-a) and the PVN (A-b). The average number of mRFP1-positive granules in the mNTS (A-c). Values represent the mean ± SEM (each group, n = 3–6). *p < 0.05 and **p < 0.01 compared with the control group (c). ^# p < 0.05 and ^## p < 0.01 compared with 0 h after administration of cisplatin group (0 h). ^$ p < 0.05 compared with 1 week after administration of cisplatin group (1w). Sections were obtained from the SON (B-a–d), PVN (B-e–h), and mNTS (B-i–l) at 0, 12, and 24 h and 1 week after administration of cisplatin. The mRFP1-positive granules are apparent (C-i–l, boxed regions). OC optic chiasma; 3V third ventricle; AP area postrema; CC central canal. Scale bar 100 μm