| |
SHR
|
SHR/H
|
SHR-mtBN
|
SHR-mtBN/H
|
|---|
|
β2 (%)
|
24.03 ± 0.30
|
31.12 ± 1.42+
|
32.97 ± 2.01*
|
31.15 ± 0.42
|
|
K
iβ2 (nM)
|
0.80 ± 0.53
|
1.43 ± 0.17
|
4.80 ± 1.25
|
0.75 ± 0.21
|
|
K
iβ1 (µM)
|
0.73 ± 0.06
|
0.77 ± 0.25
|
0.70 ± 0.07
|
0.31 ± 0.03
|
- Data are means (±SEM) of three separate experiments performed in triplicates
-
β
2
(%) percentage of β2-ARs of total myocardial β-ARs, K
i
β
2
(β
1
) apparent dissociation constant representing the affinity of ICI 118.551 to β2-ARs (β1-ARs)
- * p < 0.05 SHR vs. SHR-mtBN; + p < 0.05 SHR vs. SHR/H
