Fig. 7From: β-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxiaSchematic summarizing the main findings. Replacement of the mitochondrial genome of SHR with that of the more ischemia–resistant Brown Norway strain (mtBN) distinctly affects myocardial expression of β-ARs and MAO-A. Adaptation to chronic hypoxia is associated with partially dissimilar changes in β-ARs, MAO-A and some components of the antioxidant defence in the myocardium of SHR and SHR-mtBN. These differences may contribute to more efficient cardioprotection conferred by chronic hypoxia in SHR-mtBN, compared to progenitor SHR. The arrows indicate changes relative to SHR or to SHR-mtBN in the case of SHR-mtBN/H. β-ARs, β-adrenergic receptors; β1/β2, the β1-AR/β2-AR ratio; MAO-A monoamine oxidase A, CAT catalase, SOD superoxide dismutase, MDA malondialdehyde, up arrow (double up arrow) and down arrow, increase (higher increase) and decrease, respectivelyBack to article page