Fig. 7

Schematic summarizing the main findings. Replacement of the mitochondrial genome of SHR with that of the more ischemia–resistant Brown Norway strain (mtBN) distinctly affects myocardial expression of β-ARs and MAO-A. Adaptation to chronic hypoxia is associated with partially dissimilar changes in β-ARs, MAO-A and some components of the antioxidant defence in the myocardium of SHR and SHR-mtBN. These differences may contribute to more efficient cardioprotection conferred by chronic hypoxia in SHR-mtBN, compared to progenitor SHR. The arrows indicate changes relative to SHR or to SHR-mtBN in the case of SHR-mtBN/H. β-ARs, β-adrenergic receptors; β₁/β₂, the β₁-AR/β₂-AR ratio; MAO-A monoamine oxidase A, CAT catalase, SOD superoxide dismutase, MDA malondialdehyde, up arrow (double up arrow) and down arrow, increase (higher increase) and decrease, respectively