Fig. 2
Effect of hypoxia on activity of myocardial adenylyl cyclase. AC activity in LV preparations from SHR (empty bars), SHR/H (closed bars), SHR-mtBN (dotted bars) and SHR-mtBN/H (hatched bars) was determined in the presence of the following stimulators: 10 μM isoprenaline (ISO), 10 μM forskolin (FSK), 10 mM MnCl2 and 10 mM NaF. Differently stimulated AC activity is expressed as a percentage of the corresponding basal AC activity, which did not significantly differ between different samples and was in the range of 7.9–9.2 pmol cAMP/min per mg protein in all measurements. Data represent means (±SEM) of five independent measurements performed in triplicate. *p < 0.05 SHR vs. SHR-mtBN rats; + p < 0.05 SHR vs. SHR/H rats; § p < 0.05 SHR/H vs. SHR-mtBN/H rats; # p < 0.05 SHR-mtBN vs. SHR-mtBN/H rats