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Fig. 6 | The Journal of Physiological Sciences

Fig. 6

From: Hypotonicity-induced cell swelling activates TRPA1

Fig. 6

hTRPA1-mediated single-channel currents activated by negative pressure to the pipette or a hypotonic solution. a A representative trace of hTRPA1-mediated single-channel currents activated by negative pressure, which was adjusted to approximately 6.6 cmHg with a microliter #702 syringe (HAMILTON Company Inc., Nevada, USA). b Comparison of hTRPA1 currents with or without negative pressure. *p < 0.05. c Representative trace of the currents activated by negative pressure applied to a mock-transfected cell. d A representative trace of hTRPA1-mediated single-channel currents in the presence of the TRPA1 inhibitor HC-030031 (30 μM). e Inhibitory effects of HC-030031 (N = 6) on hTRPA1-mediated single-channel currents induced by hypotonic solution. *p < 0.05

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