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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Hypotonicity-induced cell swelling activates TRPA1

Fig. 5

Cell swelling induced by hypotonic solution activated hTRPA1. a Comparison of NPo values for single-channel currents activated by hypotonic stimulus in cells expressing hTRPA1 upon establishing a cell-attached configuration before (N = 7) and after (N = 11) exposure to −120 mOsm hypotonic solutions. *p < 0.05. b Representative traces of the single-channel currents activated by hypotonic stimulus in cells expressing hTRPA1 without and with AITC. c NPo values of single-channel currents in cells expressing hTRPA1 that were exposed to hypotonic solutions of different osmolalities (±0 mOsm, N = 8; −80 mOsm, N = 7; −120 mOsm, N = 11; −160 mOsm, N = 9). *p < 0.05 vs ±0 mOsm. d NPo values of single-channel currents in cells expressing hTRPA1 that were exposed to hypotonic solutions of different osmolalities (±0 mOsm, N = 8; −80 mOsm, N = 7; −120 mOsm, N = 10; −160 mOsm, N = 8) with 1 μM AITC. † p < 0.05; †† p < 0.01 vs ±0 mOsm. e Correlations between cA increase ratios and NPo values in cells expressing hTRPA1 that were exposed to hypotonic solutions (black circles without AITC, N = 24; black diamonds with AITC, N = 24)

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