Fig. 2

Circadian rhythms in PER2::LUC in cultured SMGs of wild-type (WT), Cry1 ^−/−, and Cry2 ^−/− mice ex vivo. a Representative bioluminescence oscillations showing PER2::LUC activity in the SMG of WT (left), Cry1 ^−/− (middle), and Cry2 ^−/− (right) mice. Hours, starting from the time when tissues were cultured, are displayed on the X-axis. Serial de-trended bioluminescence counts are plotted for 5 days. b Circadian periods of PER2::LUC rhythms in the SMG of each genotype. c The first peak phase of PER2::LUC rhythms in the SMG of each genotype. All values are the mean ± standard deviation (n = 8 in each genotype). * P < 0.01 (vs. WT, Scheffé post hoc test)