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Fig. 6 | The Journal of Physiological Sciences

Fig. 6

From: Long-term resistance exercise-induced muscular hypertrophy is associated with autophagy modulation in rats

Fig. 6

Summary of RE-induced muscular adaptation. RE-induced increase in muscle fiber cross-sectional area and strength is caused by modulating the rate of protein turnover, with protein synthesis predominating protein degradation. RE enhances an anabolic signaling nexus of hypertrophy pathways (AKT-mTOR-p70s6k) but suppresses a catabolic process, autophagy, which was evidenced by reduced AMPK phosphorylation levels, a declined LC3-I/LC3-II ratio, diminished active CATHEPSIN levels, and increased p62 levels. Our data suggest that although showing only a limited snapshot of metabolic change 24 h after the last bout of RE, sustained anabolic signaling activation may restrict autophagy-related catabolic processes, contributing to an increase in muscle fiber sizes

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