Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

Table 1 Genetic evidence for the biological relevance of ZnT transporters

Official symbol	Protein	Mutation type	OMIM Gene locus/ phenotype	Abnormality (*Phenotypes in human)	Expression	References
Slc30a1	ZnT1	KO	609521/ -	Embryonic lethal	Ubiquitous	[150]
Slc30a2	ZnT2	*Mutation	609617/ 608118	*Low Zn in milk	Widely distributed	[151,152,153,154]
Slc30a3	ZnT3	KO	602878/ -	Prone to seizures; similar to the synaptic and memory deficits of Alzheimer’s disease; required for pre-synaptic Erk activation and hippocampus-dependent memory	Brain	[155, 156]
Slc30a4	ZnT4	Mutation	602095/ -	Lethal milk mutant: low Zn in milk	Ubiquitous	[157]
Slc30a5	ZnT5	KO	607819/ -	Growth retardation, osteopenia and male-specific cardiac death; impaired mast cell functions	Ubiquitous	[158, 159]
Slc30a6	ZnT6		611148/ -		Widely distributed
Slc30a7	ZnT7	KO	611149/ -	Growth retardation, low body Zn status and low fat accumulation	Widely distributed	[160, 161]
Slc30a8	ZnT8	KO; *SNP	611145/ 125853	Impairment of insulin secretion and insulin-crystal formation; *type I and II diabetes mellitus	Pancreas	[162, 167]
Slc30a10	ZnT10	*Mutation	611146/ 613280	*Parkinsonism, hypermanganesemia, syndrome of hepatic cirrhosis, dystonia, polycythemia	Small intestine Liver Brain	[169, 170]

ISSN: 1880-6562