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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

Fig. 5

Summary of Zn transporters in physiology and pathogenesis. Biological inputs such as oxidative stress, antigen stimulation, aging, growth factors, and virus infection trigger various intracellular processes (blue square on upper side). “Modulation of Zn signals” intends the Zn ion, which is transported through individual Zn transporters, modulates various intracellular processes followed by the regulation of molecular status of their target molecules (red arrow area in the middle). Zn signal affects numerous cellular events such as migration, differentiation, proliferation and apoptosis, etc. These cellular events contribute to induce specific biological outputs such as allergy, development, immunity, nerve system and endocrine, etc. (dark blue area on lower side). The impairment of Zn transporter-mediated Zn signal will cause the progression and initiation of various diseases. Please refer to Tables 1 and 2 for reviewing individual biological functions of zinc transporters

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