Fig. 6

Simulated [Ca²⁺]_i response to stretch with different TRPC3 locations. a Stretch-induced slow increase in [Ca²⁺]_i was observed with the increase in conductance of all cations (Na⁺, K⁺, and Ca²⁺) when TRPC3 was located on the sarcolemma (no stretch: G _trpcNa, G _trpcK, G _trpcCa = 0 nS; with stretch: G _trpcNa, G _trpcK, G _trpcCa = 0.07 nS, respectively). b The [Ca²⁺]_i was unchanged with increasing cation flux when TRPC3 was located on the SR (no stretch: K _TRPC = 0 s⁻¹; with stretch: K _TRPC = 0.007 s⁻¹). c Increasing only the Na⁺ or Ca²⁺ conductance (no stretch: G _trpcNa, G _trpcCa = 0 nS; with stretch: G _trpcNa, G _trpcCa = 0.07 nS, respectively) caused SSC (trpc_Na and trpc_Ca, respectively), but increasing only the K⁺ conductance (no stretch: G _{t rpcK} = 0 nS; with stretch: G _trpcK = 0.07 nS) did not (trpc_K)