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Fig. 6 | The Journal of Physiological Sciences

Fig. 6

From: TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

Fig. 6

Simulated [Ca2+]i response to stretch with different TRPC3 locations. a Stretch-induced slow increase in [Ca2+]i was observed with the increase in conductance of all cations (Na+, K+, and Ca2+) when TRPC3 was located on the sarcolemma (no stretch: G trpcNa, G trpcK, G trpcCa = 0 nS; with stretch: G trpcNa, G trpcK, G trpcCa = 0.07 nS, respectively). b The [Ca2+]i was unchanged with increasing cation flux when TRPC3 was located on the SR (no stretch: K TRPC = 0 s−1; with stretch: K TRPC = 0.007 s−1). c Increasing only the Na+ or Ca2+ conductance (no stretch: G trpcNa, G trpcCa = 0 nS; with stretch: G trpcNa, G trpcCa = 0.07 nS, respectively) caused SSC (trpcNa and trpcCa, respectively), but increasing only the K+ conductance (no stretch: G t rpcK = 0 nS; with stretch: G trpcK = 0.07 nS) did not (trpcK)

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