Fig. 1From: Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosusHemodynamics of simple coarctation of the aorta (CoA) and complex CoA. a Hemodynamics of simple CoA. Closure of the ductus arteriosus leads to left ventricular pressure overload, resulting in left ventricular dysfunction. b In complex CoA, blood flow from the left ventricle to the right ventricle through the ventricular septal defect causes left ventricular volume overload. Subsequent increase in left ventricular endo-diastolic pressure leads to pulmonary venous and arterial hypertensionBack to article page