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Fig. 3 | The Journal of Physiological Sciences

Fig. 3

From: Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments

Fig. 3

Inhibitory effects of spinal administration of noradrenaline and its agonists on the increased firing of wide dynamic neurons in response to cold stimulation in oxaliplatin-injected rats. a Representative raw traces of WDR neuron’s activities evoked by cold stimulation (a drop of 10 μl acetone to the hind paw) before and after spinal application of noradrenaline (top panel) or α2 agonist, clonidine (bottom panel). b Inhibition rate of cold stimulation-evoked activities of wide dynamic range neurons by noradrenaline (50 μM, n = 11) or its agonists phenylephrine (α1 agonist, 50 μM, n = 4), clonidine (α2 agonist, 50 μM, n = 9), and isoprenaline (β agonist, 50 μM, n = 6). ***p < 0.001, by 1-way ANOVA. c Behavioral assessment with five cold stimulations after intrathecal drug administration shows that noradrenaline, α2, and α1 agonists generate analgesic effects on cold allodynia in accordance with electrophysiological data. **p < 0.01, ***p < 0.001, by 2-way ANOVA

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