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Fig. 1 | The Journal of Physiological Sciences

Fig. 1

From: Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments

Fig. 1

Increased behavioral response to cold stimulation caused by an oxaliplatin injection. Behavioral assessment was performed with 4-grade scoring for each behavioral response from applying 10 μl of acetone on the rat’s hind paw as innocuous cold stimulation: 0 no response, 1 brisk withdrawal or flick of the paw, 2 repeated flicking of the paw, 3 repeated flicking of the hindpaw and licking of the paw. Scores acquired from five trials of cold stimulation on the rat’s hind paw were summed (a). N = 15 for each group. Response frequency was acquired from the five trials (b). N = 15 for each group. ***p < 0.001, by Mann–Whitney test (a) and unpaired t-test (b)

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