Fig. 7
From: Expanding frontiers in weight-control research explored by young investigators
A schematic model for the relationships between NMDA-R, d-serine, and appetite. Alteration in the local d-serine concentration or sensitivity to d-serine in the neurocircuitry for feeding may affect the feeding behavior. Excessive facilitation of glutamatergic inputs through NMDA receptors by increased local d-serine concentration leads to decreases in the intake and the preference for food. Conversely, decreased local d-serine concentration may lead to increases in the intake and the preference for food