Fig. 5
From: Expanding frontiers in weight-control research explored by young investigators
Different roles of Gq- and Gs-coupled GPCRs expressed by AgRP neurons in food intake. Gq-coupled GPCRs (e.g., ghrelin receptors) stimulate the calcium signaling pathway, resulting in an acute feeding response caused by NPY and GABA release. By contrast, Gs-coupled GPCRs (e.g., PACAP receptors) stimulate the cAMP signaling pathway, resulting in long-lasting feeding caused by AgRP release