Fig. 5

Contribution of p130Cas to recovery after skin stretching. a The stretched skin by thick chamber insertion and the sham-treated skin by thin chamber insertion are shown. Skin recovery after stretching load was assessed immediately after removal of the chamber during the course of 3 weeks of treatment with PP2, an inhibitor of p130Cas. PP2 or PBS was administered 1 day before chamber removal. b The stretched skin 3 weeks after chamber removal followed by PBS injection (left panel) or PP2 injection (right). c Serial changes in relative skin deformation; the ratio of extent of skin extension under thick chamber insertion was expressed relative to the that under thin chamber insertion. Data are mean ± SD (n = 3–5) at 3 weeks after chamber removal. *p < 0.05