Fig. 3
From: Modulation of cutaneous extracellular collagen contraction by phosphorylation status of p130Cas
Effect of depression or acceleration of p130Cas signaling on the contraction of collagen gels containing NHDFs. a and c Phosphorylation of p130Cas is suppressed or accelerated by the addition of PP2 or by treatment with siRNA specific for CSK, respectively. b Contraction of NHDFs-embedded collagen gels is significantly inhibited by PP2, an inhibitor of the Src signaling pathway, which stimulates p130Cas in a dose-dependent manner. d Collagen gel contraction is enhanced by a siRNA specific for a negative regulator of Src family kinases (CSK). Data are mean ± SD (n = 3 per group). **p < 0.01. Images are representative of three independent samples