Fig. 8
Effect of RU486 pretreatment on changes in TDO and IDO activities and Trp, Kyn, and INF-γ levels in liver tissues of rats subjected (WIRS) or not (Control) to 6 h of WIRS treatment. Rats in the WIRS group were injected intraperitoneally with either RU486 (WIRS + RU486; 20 mg/kg body weight) or vehicle (WIRS; 0.5 % Tween 80) at 0.5 h before the onset of the WIRS treatment. Rats in the Control group were injected intraperitoneally with vehicle in the same manner and at the same time point. Liver TDO and IDO activities and liver Trp, Kyn, and INF-γ levels in each group were determined using the assays described in the Materials and methods. Each value is the mean ± SD (n = 7 Control WIRS; n = 8 WIRS rats; n = 8 WIRS + RU486 rats). *P < 0.05 (vs. Control rats); # P < 0.05 (vs. WIRS rats)