Fig. 2

NADPH oxidase inhibitor attenuates LPS-induced microglial H⁺ currents. a Current traces from −100 to +100 mV from the holding potential of −60 mV for 1 s are shown. LPS (1 μg/ml) was applied for 24 h and NADPH oxidase inhibitor, dibenziodolium chloride (DPI, 1 μM), was pre-treated for 1 h prior to the application of LPS. b I–V relationships in the absence of LPS (control with vehicle, filled square), with 1 μg/ml LPS (filled circle), 1 μM DPI alone (filled upright triangle), and DPI + LPS (filled downright triangle) are shown. c The relative current amplitudes at +100 mV in b are shown. *p < 0.05 compared to control. ^# p < 0.5 compared to LPS (1 μg/ml)