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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition

Fig. 5

Increased mitochondrial biogenesis is abolished by inhibiting mitophagy in mouse skeletal muscle. Representative immunoblot images of PGC-1α, SDH and COX IV (a), which are indexes of mitochondrial biogenesis. Densitometric quantification of PGC-1α (b), SDH (c), COX IV (d), and CS enzyme activity (f). Values are means ± SE; (n = 8) * p < 0.05 vs. sed+sal, # p < 0.05 vs. sed+col, δ p < 0.05 vs. exe+sal. Relative mRNA expression of PGC-1α in triceps muscles of mice was measured following 8-week of swimming exercise training. mRNA levels are relative to the GAPDH (n = 4 per group) (e). Data represent mRNA levels are relative to the GAPDH (n = 4 per group). Amount of mitochondrial DNA (16s rRNA) adjusted by nuclear DNA (hexokinase 2) in triceps muscles isolated from the control and swimming trained mice (n = 4 per group) (g)

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