Fig. 3
From: Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor
TRPV2 activation by peristalsis relaxes intestinal muscle tone. The inhibitory motor neurons (yellow) express TRPV2 in the intestine (beige) as shown by red images. The TRPV2 is activated by membrane stretch derived from peristalsis shown by black arrows. The activation of TRPV2 caused high Ca2+ influx and NO release. The NO release relaxes muscle tone, and contributes to transit within the gastrointestinal tract