Fig. 6

Effect of EDHB preconditioning on HIF-1α, PHD2, VEGF and antioxidant proteins HO-1 and MT-1 in rat brain with/without EDHB supplementation exposed to normoxia and hypoxia (9144 m, 5 h). a Western blots of HIF-1α, PHD2, VEGF, HO-1 and MT-1. b Bar graph representation. Bands were analyzed with densitometry using Image-J software. Values are in relative optical density. C control, H hypoxia, D drug, DH drug + hypoxia. Data is the mean ± SD (n = 8). (C vs. H ^a p < 0.01, ^d p < 0.05; H vs. DH ^b p < 0.01, ^c p < 0.05)