Fig. 1

Dose response study of EDHB based on hypoxia gasping time (HST) and hypoxia survival time (HST). EDHB supplemented animals (50, 75, 100 mg/kg b.wt. for 3 and 5 days) were subjected to an altitude of 9754 m (32,000 ft.) at 32 °C in animal decompression chamber. On the basis of hypoxia gasping and survival time recorded to measure hypoxia tolerance EDHB dose with 75 mg/kg b.wt for 3 days was selected for further studies. Values are mean ± SD (n = 8/group). (Control vs. EDHB ^a p < 0.01; 3 vs. 5 days ^b p < 0.01, ^c p < 0.05)