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Fig. 4 | The Journal of Physiological Sciences

Fig. 4

From: Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8

Fig. 4

Changes in thermal sensitivity of hTRPV1 and hTRPM8 by menthol and capsaicin. a A representative trace of the hTRPV1-mediated heat-activated currents (upper) with changes in temperature (lower). The hTRPV1 response was confirmed by capsaicin (10 µM). b Comparison of the first heat-evoked hTRPV1-mediated current densities in the absence and presence of 5 mM menthol in HEK293T cells (n = 10–13). *p < 0.05. c A representative trace of the hTRPM8-mediated cold-activated currents (upper) with changes in temperature (lower). The hTRPM8 response was confirmed by menthol (1 mM). d Comparison of the first cold-evoked hTRPM8-mediated current densities in the absence and presence of 100 µM capsaicin in HEK293T cells (n = 10–12). **p < 0.01. e, f Temperature thresholds for heat-evoked hTRPV1 activation determined by Arrhenius plots from the data in the absence (42.3 °C; e) and presence (41.6 °C; f) of 5 mM menthol in HEK293T cells expressing hTRPV1. g The average temperature thresholds for hTRPV1 activation after the first heat stimulation in the absence and presence of 5 mM menthol in HEK293T cells (n = 6–7). Data are shown as the mean ± SEM

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