Fig. 3

Inhibition of heat-evoked hTRPV1 and cold-evoked hTRPM8 responses by menthol and capsaicin. a, b Changes in the Fura-2 ratio in response to heat stimulation (>45 °C) in the absence (a) and presence (b) of menthol (6 mM) in HEK293T cells expressing hTRPV1 (n = 61). c Changes in the Fura-2 ratio in response to cold stimulation (<20 °C) in the presence and absence of capsaicin (1 mM) in HEK293T cells expressing hTRPM8 (n = 117). Data are shown as the mean ± SD