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Table 2 Respiratory measures quantified at different times of the day

From: Plethysmography measurements of respiratory function in conscious unrestrained mice

Variable

7:30 a.m.

11:45 a.m.

3:00 p.m.

6:00 p.m.

p value

Respiratory rate

378 ± 2a

411 ± 16a

432 ± 19b

403 ± 25a

0.037

Tidal vol/wt (ml/kg*100)

1.21 ± 0.12a

1.31 ± 0.14b,c

1.35 ± 0.15b

1.20 ± 0.16a,c

0.014

Minute ventilation (ml/min)

94.7 ± 7.89a

109.5 ± 7.63b

118.1 ± 8.77b

109.3 ± 9.46a

0.013

Expiratory time (s)

0.14 ± .01a

0.11 ± 0.01b

0.11 ± 0.01b

0.13 ± 0.01a,b

0.038

Inspiratory time (s)

0.06 ± 0.004

0.05 ± 0.003

0.05 ± 0.002

0.06 ± 0.004

0.180

Peak inspiratory flow (ml/s)

7.79 ± 0.51

8.52 ± 0.54

9.05 ± 0.54

8.73 ± 0.63

0.065

Peak expiratory flow (ml/s)

4.48 ± 0.39a

5.14 ± 0.42b

5.41 ± 0.45c

5.08 ± 0.43b

0.014

Time to relaxation (s)

0.07 ± .01a

0.06 ± 0.003b

0.06 ± 0.01b

0.07 ± 0.01a,b

0.020

  1. Data are mean ± SEM
  2. a,b,cdenote statistically different time points. Statistical differences p ≤ 0.05