Fig. 7
From: Mechanisms of astrocytic K+ clearance and swelling under high extracellular K+ concentrations
Simulated drug effects on K+ spatial buffering in a non-uniform distribution of high [K+]out. a Simulated drug effects on KIR currents for K+ uptake at the perisynaptic membrane. KIR currents and intracellular ion concentrations were simulated under the [K+]out conditions used in Fig. 6a. Simulation results without blocking are shown as dotted lines, b simulated effects of various block levels on KIR currents at the perisynaptic membrane. The effects of various block levels were calculated at the end of 30-min sessions, and c simulated drug effects on KIR currents for K+ release into the perivascular space. KIR currents and intracellular ion concentration were simulated under the [K+]out conditions used in Fig. 6c, and d simulated effects of various block levels on KIR currents in the perivascular space. The effects of various block levels were calculated at the end of 30-min sessions